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Is phycocyanin a potential remedy for allergies?

by | Mar 19, 2021 | advice, Phycocyanin, Science, Well-being | 0 comments

What are the different types of allergies? How do they manifest themselves? How is phycocyanin an interesting element in the fight against allergies?

Sources and types of allergies

Our body is constantly confronted with external enemies: microbes, viruses, bacteria.

But it also faces harmless basic enemies for the body

Allergy is a hypersensitivity of the body, a failure of the immune system to generally harmless substances.

The frequency of allergies has been steadily increasing in recent years. In France, 25 to 30% of the general population has an allergy.

We distinguish different types of allergies:

  • food: cow’s milk, egg, peanuts, mustard, fish, nuts, etc.

  • respiratory: mites, molds, pollens, cats, dogs, rodents and horses …

  • of contact with the skin: components of cosmetics, detergents, metals, etc.

  • medicinal products: antibiotics, anesthetics, etc.

  • professional: latex, flour, cement, formalin …

To fight them, he has a powerful weapon: the immune system.

The operating mode at the biological level:

The allergy then manifests itself when the body “meets” the allergen, a reaction of rejection of the immune system which considers the substance eaten, drunk, touched or inhaled as a serious enemy is triggered.

Indeed, the organism, instead of defending us against a real aggression, goes wrong and begins to react against the allergens of which the person is sensitized.

The body will then react to molecules that it perceives as harmful but which in itself would not be, then follows the activation of the cells of the immune system which will (1) destroy the allergen and (2) release substances (chemical mediators of inflammation) that will send signals to other immune defense cells.

The immune cells thus activated release inflammation mediators into the extracellular environment, the combined effects of which will allow the recruitment of circulating cells, the elimination of the pathogen and the repair of the lesion.

The reactions observed during an allergic manifestation are mainly due to these chemical mediators which cause the inflammations.

This reaction results in particular in the production of antibodies specific to allergy – IgE (Immunoglobulin E).

Phycocyanin? A potential cure:

Phycocyanin is a protein found in the photosynthetic apparatus of spirulina. It is composed of a protein base (apoprotein) made of two small proteins α and β and three molecules of phycocyanobilin.

Apoprotein and phycocyanobilin have very powerful antioxidant properties. Once in the body, phycocyanobilin is converted into a molecule similar to bilirubin [1] which is a powerful natural antioxidant and a component of hemoglobin.

These antioxidants are key elements in the elimination of free radicals that cause significant damage to our body by attacking the tissues and cells of our body causing premature aging and the onset of disease. When free radicals become too large for our reserves of antioxidants, then an imbalance is created and it becomes impossible to fight against the devastating effects of free radicals. To fight effectively, it is necessary to increase our reserves by consuming a powerful antioxidant which has shown its exceptional benefits on our body.

Phycocyanin would not only inhibit the production of IgE [2] and histamine [3], but also increase the level of immunoglobulin A (IgA), which is an antibody that strengthens the immune system. Continued consumption of phycocyanin would prepare the immune system upon exposure to the allergenic substance and lead to a significant decrease in allergy symptoms.

SOURCES General explanations of allergies

https://allergies.afpral.fr/allergie/decouvrir-les-allergies/qu-est-ce-qu-une-allergie

https://www.ameli.fr/assure/sante/themes/allergies/comprendre-allergies

Explanation of the molecules and cells involved in inflammation

http://acces.ens-lyon.fr/acces/thematiques/immunite-et-vaccination/thematiques/immunite-innee-barrieres-naturelles-et-reaction-inflammatoire/les-mediateurs-de-l2019inflammation#:~:text=A%20%2D%20Les%20cellules%20immunitaires%20r%C3%A9sidantes,les%20lymphocytes%20T%20et%20B.

 

SCIENTIFIC REFERENCES

[1] Eriksen (2008) Production of phycocyanin-a pigment with applications in biology, biotechnology, foods and medicine. Applied Microbiology and Biotechnology, 80: 1-14.

[2] Nemoto-Kawamura C., Hirahashi T., Nagai T., Yamada H., Katoh T. and Hayashi O. (2004) Phycocyanin enhances secretary IgA qntibody response and suppresses allergic IgE antibody response in mice immunized with antigen-entered biodegradable microparticles. Journal of Nutritional Science and Vitaminology 50 (2): 129-136

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